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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL4
All Species:
19.09
Human Site:
S238
Identified Species:
32.31
UniProt:
Q5MAI5
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5MAI5
NP_001009565.1
315
36223
S238
N
G
F
F
H
G
I
S
I
P
E
P
E
D
M
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001103311
378
43278
S238
N
R
F
F
H
G
I
S
I
P
E
P
E
D
M
Dog
Lupus familis
XP_851459
362
41706
S258
N
Q
F
F
H
G
I
S
I
P
E
P
E
D
M
Cat
Felis silvestris
Mouse
Mus musculus
Q3TZA2
342
39427
S238
N
Q
F
F
R
G
I
S
I
P
E
P
E
D
M
Rat
Rattus norvegicus
Q66HE7
352
40881
K239
N
Q
Y
F
S
G
V
K
I
P
D
P
E
D
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514378
352
40807
R239
N
Q
F
F
S
G
V
R
I
P
D
P
E
N
T
Chicken
Gallus gallus
P13863
303
34670
F241
L
Q
D
Y
K
N
T
F
P
K
W
K
P
G
S
Frog
Xenopus laevis
P23437
297
33852
F240
M
P
D
Y
K
S
T
F
P
K
W
I
R
Q
D
Zebra Danio
Brachydanio rerio
Q6AXJ9
350
40792
C239
N
Q
F
F
S
G
V
C
V
P
E
P
Q
E
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_608950
501
57855
T347
N
E
Y
F
K
G
I
T
L
P
V
P
P
T
L
Honey Bee
Apis mellifera
XP_394980
385
44993
I262
N
E
F
F
A
G
I
I
L
P
T
P
Q
T
L
Nematode Worm
Caenorhab. elegans
NP_505823
353
40647
S238
N
Q
F
F
F
G
L
S
I
P
E
P
E
H
L
Sea Urchin
Strong. purpuratus
XP_787618
363
41882
G239
S
T
N
H
F
F
K
G
M
S
I
P
E
P
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
L234
S
W
P
G
V
S
C
L
P
D
F
K
T
A
F
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
79.8
80.3
N.A.
83.3
62.7
N.A.
62.5
38.4
38
64
N.A.
38.7
51.4
53.8
56.4
Protein Similarity:
100
N.A.
81.2
83.1
N.A.
90
76.6
N.A.
75.8
57.4
60
77.7
N.A.
51.5
67
70.5
71
P-Site Identity:
100
N.A.
93.3
93.3
N.A.
86.6
60
N.A.
53.3
0
0
53.3
N.A.
40
46.6
66.6
13.3
P-Site Similarity:
100
N.A.
93.3
93.3
N.A.
86.6
80
N.A.
73.3
6.6
6.6
80
N.A.
66.6
66.6
80
26.6
Percent
Protein Identity:
N.A.
35.8
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
56.8
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
0
0
0
0
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
8
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
15
0
0
0
0
0
0
8
15
0
0
36
8
% D
% Glu:
0
15
0
0
0
0
0
0
0
0
43
0
58
8
8
% E
% Phe:
0
0
58
72
15
8
0
15
0
0
8
0
0
0
8
% F
% Gly:
0
8
0
8
0
72
0
8
0
0
0
0
0
8
0
% G
% His:
0
0
0
8
22
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
0
0
0
0
43
8
50
0
8
8
0
0
0
% I
% Lys:
0
0
0
0
22
0
8
8
0
15
0
15
0
0
0
% K
% Leu:
8
0
0
0
0
0
8
8
15
0
0
0
0
0
22
% L
% Met:
8
0
0
0
0
0
0
0
8
0
0
0
0
0
43
% M
% Asn:
72
0
8
0
0
8
0
0
0
0
0
0
0
8
0
% N
% Pro:
0
8
8
0
0
0
0
0
22
72
0
79
15
8
0
% P
% Gln:
0
50
0
0
0
0
0
0
0
0
0
0
15
8
0
% Q
% Arg:
0
8
0
0
8
0
0
8
0
0
0
0
8
0
0
% R
% Ser:
15
0
0
0
22
15
0
36
0
8
0
0
0
0
8
% S
% Thr:
0
8
0
0
0
0
15
8
0
0
8
0
8
15
8
% T
% Val:
0
0
0
0
8
0
22
0
8
0
8
0
0
0
0
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
15
0
0
0
0
% W
% Tyr:
0
0
15
15
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _